Monocentric prospective study for assessing the efficacy and tolerability of a cosmeceutical formulation in patients with melasma

Eloisa Leis Ayres,José Euzébio Gonçalves Júnior,Miriam Szrajbman,Adriana Chaib Ferreira Jorge,Adilson Costa,Beatriz Sant’Anna

doi:10.5935/scd1984-8773.201683832

Abstract

Introduction: Melasma is a common pigmentary condition that affects exposed body areas, especially in the frontal and malar regions. Hydroquinone is...

Highlights

Melasma is a common pigmentary condition that affects exposed body areas, especially in the frontal and malar regions
The dermal compartment is capable of controlling cutaneous pigmentation, since the latter is regulated by a complex melanogenic network in which both keratinocytes and fibroblasts synthesize growth factors and cytokines, such as the hepatocyte growth factor (HGF), the keratinocyte growth factor (KGF) and the stem cell factor (SCF), which in turn directly influence pigmentation.[14,15]
The present study evaluated the following parameters: L*; and ITA, which is the individual typological angle obtained by the formula ITA° = [Arc Tangent ((L* - 50) / b*)] 180 / π.The angle ITA° is proportionally related to the skin’s pigmentation, with narrower angles indicating greater pigmentation and wider angles, lesser pigmentation

Summary

Introduction

Melasma is a common pigmentary condition that affects exposed body areas, especially in the frontal and malar regions. Objective:To evaluate the efficacy and tolerability of a cosmeceutical formulation containing ellagic acid, hydroxyphenoxy propionic acid, yeast extract and salicylic acid in Brazilian patients with mild to moderate melasma. Results: After 90 days of treatment, a significant improvement could be observed in the clinical and colorimetric parameters evaluated, and in the quality of life questionnaire. Conclusions:The evaluated cosmeceutical formulation was proven as an effective alternative to hydroquinone for the treatment of melasma, with excellent cutaneous tolerability profile. Melasma is a frequent pigmentary disease that manifests as symmetrical hyperpigmented macules on the skin,[1] and affects exposed body areas, especially the frontal and malar regions.[2,3]. The pigment may be located in the epidermis, dermis or in both (mixed location).[10,11,12] The relevance of this classification dwells is the fact that it can be instrumental in determining the most adequate treatment and prognosis.[1,13] the dermal compartment is capable of controlling cutaneous pigmentation, since the latter is regulated by a complex melanogenic network in which both keratinocytes and fibroblasts synthesize growth factors and cytokines, such as the hepatocyte growth factor (HGF), the keratinocyte growth factor (KGF) and the stem cell factor (SCF), which in turn directly influence pigmentation.[14,15]

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Methods

Results

Discussion

Conclusion