Abstract
The plasma membrane monoamine transporters and vesicular monoamine transporters (VMATs) have a major role in regulation of the synaptic homeostasis and effects of dopamine (DA), norepinephrine (NE), and serotonin (5-hydroxytryptamine [5-HT]). Both groups of transporters are members of the soluble carrier (SLC) superfamily. The plasma membrane transporters belong to the SLC6 family and use the electrochemical gradient of sodium (Na+) as their driving force; they include the transporters for DA (DAT), NE (NET), and 5-HT (SERT). These transporters are expressed in the dendrites and axons of their respective monoaminergic neurons and mediate the rapid uptake of synaptically released neurotransmitter from the extracellular space. By this mechanism, these transporters are major determinants of monoaminergic synaptic signaling.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
