Abstract
Uzbekov M1*, Brilliantova V2 and Shikhov S3 Author Affiliations 1Head of the Laboratory of Brain Pathology, Moscow Research Institute of Psychiatry, Russia 2Junior researcher, Laboratory of Brain Pathology, Moscow Research Institute of Psychiatry, Russia 3Senior researcher, Laboratory of Brain Pathology, Moscow Research Institute of Psychiatry, Russia Received: November 14, 2019 | Published: November 21, 2019 Corresponding author: Uzbekov M, Professor, Head of the Laboratory of Brain Pathology, Moscow Research Institute of Psychiatry, Russia DOI: 10.26717/BJSTR.2019.23.003856
Highlights
Therapy of patients with first episode of schizophrenia (FES) is a complicated task for psychiatrists
Patients with FES were characterized by a significant increased activity of platelet monoamine oxidase (MAO) and decreased sensitive amine oxidase (SAO) activity in the blood serum, as compared to the control (Table 1)
Our study showed that FES is characterized by biochemical disturbances: a significant increase in the activity of platelet MAO, which may reflect MAO activity in the brain [6], and a decrease in the sensitive amine oxidase (SSAO) activity
Summary
Therapy of patients with first episode of schizophrenia (FES) is a complicated task for psychiatrists. Diagnosis and effective therapy are key steps for achieving the long-term positive outcomes among such kind of patients. It is very important to study the pathophysiological mechanisms of first episode of schizophrenia. The current diagnosis of schizophrenia remains subjective for many reasons and one of them is the lack of biological markers of the disease. The identification of biological markers of psychosis is a fundamental step towards a better understanding of pathogenetic mechanisms of psychosis and holds the potential for developing more objective testing method [2]. Neurochemical studies help to understand the pathogenetic mechanisms of schizophrenia, including the first episode of the disease, and to create antipsychotic drugs with new characteristics and new targets. The aim of the study was to investigate the activity of platelet monoamine oxidase (MAO) and semi carbazide-sensitive amine oxidase (SSAO) in the blood serum of drug-naïve first episode (FES) schizophrenic patients
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