Abstract
To investigate the possible dysfunction of monoamine metabolism in patients with early-onset, epileptic encephalopathies. The CSF dopamine, serotonin and biopterin metabolites were studied in 37 patients with severe, mostly drug-resistant epilepsy. No significant abnormality was found, whatever the type of epilepsy, cryptogenic or symptomatic. The present study failed to demonstrate that dysfunction of the main neurotransmitters pathways is a common phenomenon in children with early-onset, severe epileptic encephalopathy.
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