MONO-NUCLEATED TRANSITION METAL (M2+) COMPLEXES OF A NEW SCHIFF-BASE AS LIGAND: SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY

Abstract

We have synthesized a new class of Schiff-base Ligands with m-pthaladehyde and 3-amino benzoic acid. This adduct act as bi-dentate (N8#x38;O) ligand in the formation of mononuclear transition metal complexes of nickel (II), zinc (II), copper (II), cobalt (II), and cadmium (II). Ligand and complexes are characterized and their formation was confirmed by spectroscopic techniques i.e. 1HNMR, FTIR, and UV-Vis spectroscopy. We have synthesized Ligand-metal coordination sphere [M2+(L)2] (where M = Cu(II), Co(II), Cd(II),Ni(II)and Zn(II)) and L=3,3'-((1E,1'E)-(1,3 phenylenebis (methanylylidene)) bis (azanylylidene)) dibenzoic acid and (E)-N-((1H-indol-3-yl) methylene)-4H-1,2,4-triazole-4- amine. Both Ligand and their metal complexes showed magnificent antimicrobial property against Pseudomonas aeruginosa (MTCC 741) which causes nosocomial infections and E. coli (MTCC 1610) which causes intestinal infection.