Abstract
X-ray coronary angiography is an invaluable tool for the diagnosis of coronary artery disease. However, the use of iodine-based contrast media can be contraindicated for patients who present with chronic renal insufficiency or with severe iodine allergy. These patients could benefit from a reduced contrast agent concentration, possibly achieved through application of a mono-energetic x-ray beam. While large-scale synchrotrons are impractical for daily clinical use, the technology of compact synchrotron sources strongly advanced during the last decade. Here we present a quantitative analysis of the benefits a compact synchrotron source can offer in coronary angiography. Simulated projection data from quasi-mono-energetic and conventional x-ray tube spectra is used for a CNR comparison. Results show that compact synchrotron spectra would allow for a significant reduction of contrast media. Experimentally, we demonstrate the feasibility of coronary angiography at the Munich Compact Light Source, the first commercial installation of a compact synchrotron source.
Highlights
X-ray imaging is an invaluable diagnostic tool in clinical practice
Even though there are some drawbacks related to the use of gadolinium for x-ray coronary angiography, such as a reduced image quality due to the lower possible concentration, several studies have shown the feasibility of applying gadolinium for patients with e.g. severe iodine allergy[9,10,11,12,13,14]
We present experimental coronary angiography data acquired at the Munich Compact Light Source (MuCLS) of a porcine heart using iodine-based contrast media at an x-ray energy of 35 keV
Summary
X-ray imaging is an invaluable diagnostic tool in clinical practice. While conventional x-ray tubes are well established and reliable in clinical x-ray imaging, their broad bremsstrahlung spectra impose a number of drawbacks with respect to image quality. 3rd generation synchrotron sources offer highly brilliant and monochromatic x-ray beams, but their high spatial and financial demands make their clinical use impracticable. Even though there are some drawbacks related to the use of gadolinium for x-ray coronary angiography, such as a reduced image quality due to the lower possible concentration, several studies have shown the feasibility of applying gadolinium for patients with e.g. severe iodine allergy[9,10,11,12,13,14]. A 90 kVp conventional x-ray tube spectrum and a 55 keV quasi-mono-energetic spectrum are examined for the application of gadolinium-based contrast media. We present experimental coronary angiography data acquired at the Munich Compact Light Source (MuCLS) of a porcine heart using iodine-based contrast media at an x-ray energy of 35 keV
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