Abstract
Acetyl hypofluorite, made easily from diluted fluorine and AcONa is very efficient in fluorinating anionic centers. Compounds containing the moieties CH2SO2 or COCH2PO react with bases to create the corresponding anions which can react with AcOF to produce derivatives containing either the CHFSO2 or COCHFPO groups. Larger excess of base and AcOF result in the difluoro compounds containing the CF2SO2 or COCF2PO sub-structures. The fluorinations proceed fast and smoothly and usually with very good yield even when the base is dissolved in aqueous solution as is the case with K2CO3 or NaHCO3.
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