Abstract
Venous stasis ulcers is a frequent clinical problem. Objective techniques for characterization and monitoring of wound healing are needed including noninvasive study of biochemical changes associated with the healing process. (31) P magnetic resonance spectroscopy was not used in the past to study human wound healing in vivo. (31) P magnetic resonance spectroscopy with study of intracellular pH, phosphocreatine, and the phosphocreatine/inor-ganic phosphate ratio was used. Six patients with venous leg ulcer and three controls were studied. Both intracellular pH, phosphocreatine and the phos-phocreatine/inorganic phosphate ratio were found sensitive indicators of wound healing. Surprisingly the intracellular pH in healing ulcers was in the alkali range. (31) P magnetic resonance spectroscopy was found useful for the study of biochemical changes associated with wound healing. pH in the alkali range was an unexpected observation.
Published Version
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Schedule a callMore From: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
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