Abstract
Background: A special attention has been given to the possible neuroprotective effects of lithium chloride (LiCl), because of his regulatory effects on pro and antiapoptotic proteins. Low LiCl concentration has a significant positive effect in synaptic plasticity and reduces tau phosphorylation in neuronal cell culture studies for distinctmechanisms.Methods: Primary cultures of cortical and hippocampal neurons were treated after 4 days in culture (DIC), and were incubated (37 C, 5% CO 2) with different concentrations of lithium chloride until to 10 days in culture. Working concentrations of lithium were 0.02mM, 0.2mM and 2mM. The effects of lithiumon PKA, AKt and Tau protein was determined by Western-blot. Results: The AKT showed an increase dose response in hippocampal neurons and showed no difference in cortical neurons. The protein PKA increased dose response both in cortical and hippocampal neurons . The tau protein accompanies an increase in hippocampal neurons and showed no difference in cortical neurons.Conclusions:Chronic treatment with subtherapeutics and therapeutics doses of LiCl increased protein tau, suggesting that tau incresead occurred by PKA in hippocampal neurons.
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