Abstract
The presence of endogenous digoxin-like immunoreactive substance (DLIS) has been reported in several clinical conditions. Because DLIS is absent in protein-free ultrafiltrates of sera, the monitoring of the serum free glycoside concentrations (f-SGC) rather than the total glycoside concentrations (t-SGC) seems more appropriate. We conducted the present study to obtain basic information about monitoring f-SGC in patients receiving beta-methyldigoxin (BMD), using TDx digoxin assay.The results showed that accuracy of the f-SGC detected with TDx assay is almost equal to t-SGC. Additionally, although the BMD-digoxin ratio has some influence on the evaluation of f-SGC, the impact seemed negligible if individual variance in the albumin concentration is taken into account. These findings suggest that the monitoring of f-SGC rather than t-SGC, is satisfactorily applicable in clinical situations.
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Schedule a callMore From: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
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