Abstract
In recent times the concept that G protein-coupled receptors (GPCRs) can exist and potentially function as dimers or higher oligomers has become widely accepted. By considering GPCR-G protein fusion proteins as bi-functional polypeptides we have generated complementary pairs of non-functional mutants that are able to reconstitute function when co-expressed. Importantly for studies on the selectivity of GPCR hetero-dimerisation this allows development of assays in which the hetero-dimer, but not the co-expressed homo-dimers, are functional. The concept that GPCR hetero-dimers display distinct pharmacology can thus be tested directly.
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