Abstract
Background: The availability of a number of agents that are efficacious in patients with metastatic prostate cancer (mPC) has led to them being used sequentially, and this has prolonged patient survival. However, in order to maximize their efficacy, clinicians need to be able to obtain a reliable picture of disease evolution by means of monitoring procedures. Methods: As the intensive monitoring protocols used in pivotal trials cannot be adopted in everyday clinical practice and there is no agreement among the available guidelines, a multidisciplinary panel of Italian experts met to develop recommendations for monitoring mPC patients using a modified Delphi method. Results: The consensus project considered methods of clinically, radiographically, and biochemically monitoring patients with metastatic hormone-sensitive and metastatic castration-resistant prostate cancer undergoing chemotherapy and/or hormonal treatment. The panelists also considered the methods and timing of monitoring castration levels, bone health, and the metabolic syndrome during androgen deprivation therapy. Conclusions: The recommendations, which were drawn up by experts following a formal and validated consensus procedure, will help clinicians face the everyday challenges of monitoring metastatic prostate cancer patients.
Highlights
The prognosis of patients with metastatic prostate cancer has dramatically improved over the last 10 years as a result of the introduction of a number of agents that are capable of significantly improving the overall survival of castration-resistant patients in everyday clinical practice.Patients with metastatic castration-resistant prostate cancer can be managed using two chemotherapeutic agents, docetaxel [1] and cabazitaxel [2]; two new androgen-receptor targeting agents (ARTAs), abiraterone acetate [3,4] and enzalutamide [5,6]; and one radiotherapeutic agent, radium 223 [7]
The results are described via the statements discussed by the consensus panelists, which were summarized in the Table 1
Are there any factors that could influence the baseline monitoring plan of an metastatic castration-sensitive prostate cancer (mCSPC) patient who is a candidate for Androgen Deprivation Therapy (ADT) alone?
Summary
The prognosis of patients with metastatic prostate cancer (mPC) has dramatically improved over the last 10 years as a result of the introduction of a number of agents that are capable of significantly improving the overall survival of castration-resistant patients in everyday clinical practice.Patients with metastatic castration-resistant prostate cancer (mCRPC) can be managed using two chemotherapeutic agents, docetaxel [1] and cabazitaxel [2]; two new androgen-receptor targeting agents (ARTAs), abiraterone acetate [3,4] and enzalutamide [5,6]; and one radiotherapeutic agent, radium 223 [7]. The prognosis of patients with metastatic prostate cancer (mPC) has dramatically improved over the last 10 years as a result of the introduction of a number of agents that are capable of significantly improving the overall survival of castration-resistant patients in everyday clinical practice. The intensive monitoring protocols used in pivotal trials clearly cannot be adopted in everyday clinical practice, but there is still no agreement concerning the frequency or methods of monitoring. The availability of a number of agents that are efficacious in patients with metastatic prostate cancer (mPC) has led to them being used sequentially, and this has prolonged patient survival. Methods: As the intensive monitoring protocols used in pivotal trials cannot be adopted in everyday clinical practice and there is no agreement among the available guidelines, a multidisciplinary panel of Italian experts met to develop recommendations for monitoring mPC patients using a modified Delphi method
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
