Abstract
Selective internal radiation therapy (SIRT) is a promising treatment modality for advanced hepatocellular carcinoma or metastatic liver cancer. SIRT is usually well tolerated. However, in most patients, SIRT will result in a (temporary) decreased liver function. Occasionally patients develop radioembolization-induced liver disease (REILD). In case of a high tumor burden of the liver, it could be beneficial to perform SIRT in two sessions enabling the primary untreated liver segments to guarantee liver function until function in the treated segments has recovered or functional hypertrophy has occurred. Clinically used liver function tests provide evidence of only one of the many liver functions, though all of them lack the possibility of assessment of segmental (regional) liver function. Hepatobiliary scintigraphy (HBS) has been validated as a tool to assess total and regional liver function in liver surgery. It is also used to assess segmental liver function before and after portal vein embolization. HBS is considered as a valuable quantitative liver function test enabling assessment of segmental liver function recovery after regional intervention and determination of future remnant liver function. We present two cases in which HBS was used to monitor total and regional liver function in a patient after repeated whole liver SIRT complicated with REILD and a patient treated unilaterally without complications.
Highlights
Radioembolization ( called selective internal radiation therapy or Selective internal radiation therapy (SIRT)) is a form of brachytherapy in which intra-arterially injected 90 Y-loaded microspheres serve as sources for internal radiation purposes of non-resectable liver tumors
Radioembolization is a form of brachytherapy in which intra-arterially injected 90 Y-loaded microspheres serve as sources for internal radiation purposes of non-resectable liver tumors
Hepatobiliary scintigraphy (HBS) is considered as a valuable quantitative liver function test enabling assessment of segmental liver function recovery after regional intervention and determination of future remnant liver function
Summary
Radioembolization ( called selective internal radiation therapy or SIRT) is a form of brachytherapy in which intra-arterially injected 90 Y-loaded microspheres serve as sources for internal radiation purposes of non-resectable liver tumors. In most patients, SIRT will result in a (temporary) decreased liver function. Used liver function tests provide evidence of only one of the many liver functions, though all of them lack the possibility of assessment of segmental (regional) liver function.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
