Abstract
The purpose of the work was to conduct a comparative analysis of the quantitative and qualitative composition of the microbiota of the urogenital system in different segments of the population of Dnipro for the period of 1 January - 31 August, 2020. Material and methods. To study the microbial landscape and determine the levels of resistance to antimicrobial drugs variants of microorganisms circulating in the urogenital tract, were examined 176 people of different ages and genders – patients of the Medical Diagnostic Center at the Dnieper Medical Academy (Dnipro) for the period of 1 January - 31 August, 2020. Results and discussion. According to the results of the microbiological study, the fact of development of infectious processes was established in 86 people, which accounted for 32.31% of cases. When studying the microbial landscape of the reproductive system of the examined patients, there was the following spectrum of priority pathogens of urogenital infections: in children and adolescents: Klebsiella oxytoca, Haemophilus influenzae / H. parainfluenzae, Escherichia coli, Streptococcus agalactiae; in women: Candida albicans, Streptococcus agalactiae, Escherichia coli, Ureaplasma spp.; in men: Ureaplasma spp. and Escherichia coli. During the monitoring of the proliferation of antibiotic-resistant variants of microorganisms – pathogens of infectious processes, the highest levels of resistance in isolated clinical isolates in relation to the drugs of classes were established: fluoroquinolons – 29.16%, cephalosporins – 18.75% and carbopenems – 10.42% of cases. Conclusion. With the use of test systems "Femoflor" and "Androflor" the species spectrum of pathogens of dysbiotic conditions of the urogenital tract in 88 patients aged 17-75 years with the help of polymerase chain reaction in real time was investigated. The incidence of detection of conventional pathogenic and pathogenic microorganisms from the urogenital sphere of women and men and the ratio of aerobic and anaerobic microbiota in dysbiotic syndromes is shown. According to the results of the study, 60.97% of women and 76.59% of men had significant deviations toward reducing the titers of representatives of the symbiotic microbiota – bacteria of the genus Lactobacilllus on the background of increasing quantitative indicators of conventional pathogenic microorganisms Gardnerella vaginalis etc., Eubacterium spp., Ureaplasma spp., Candida spp., Anaerococcus spp., Bacteroides spp. etc., Enterobacterium spp., and the presence of pathogenic microorganisms Mycopasma genitalium, Trichomonas vaginalis, Chlamydia trachomatis, Ureaplasma parvum in significant titras
Highlights
In recent years, on the background of increasing urbanization, changes in lifestyle and living conditions, deteriorating environmental conditions, diet, hypovitaminosis and increasing the number of immunodeficiency conditions, the incidence of urogenital infections is growing [1]
To study the microbial landscape and determine the levels of resistance to antimicrobial drugs variants of microorganisms circulating in the urogenital tract, were examined 176 people of different ages and genders – patients of the Medical Diagnostic Center at the Dnieper Medical Academy (Dnipro) for the period of 1 January - 31 August, 2020
To study the microbial landscape and determine the levels of resistance to antimicrobial drugs variants of microorganisms circulating in the urogenital tract, were examined 176 people of different ages and genders – patients of the Medical Diagnostic Center at the Dnieper Medical Academy (Dnipro) for the period of 1 January – 31 August, 2020
Summary
On the background of increasing urbanization, changes in lifestyle and living conditions, deteriorating environmental conditions, diet, hypovitaminosis and increasing the number of immunodeficiency conditions, the incidence of urogenital infections is growing [1]. The main issue is the timely detection of inflammation with the use of modern methods of laboratory diagnosis, the purpose of which is to prevent reproductive losses, opportunistic infections and dysbiosis [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]. The method of polymerase chain reaction in real time allows to detect pathogens even at low concentrations, to conduct etiological diagnosis in the early stages, to assess the qualitative and quantitative content of urogenital biocenosis, to control the quality of the bioassay and the effectiveness of therapy. The trigger for the reduction of genital pathology is the creation of proper monitoring, an effective system of prevention and adequate treatment with chemotherapeutic drugs [3,4,5,6,7,8, 10,11,12,13,14,15,16,17,18,19,20,21]
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