Abstract
Aortic reconstructive surgery is associated with post-ischemic reperfusion and oxidative stress. It is expected that oxidative stress should be self-limiting during healing process in the postoperative period. Lipid hydroperoxides (LHP) are one of oxidative stress markers therefore we evaluated changes in LHP level in the course of uncomplicated healing in patients who underwent abdominal aortic reconstruction. Ten male patients, aged 56–74 years (mean 65.5 ± 6.01) with abdominal aortic aneurysm or aortoiliac occlusive disease were submitted to aortic grafting operation. LHP concentration was measured in blood samples collected via central line prior to (P), at the end of (E) and 1 h, 24 h, 48 h and 72 h after surgery. The results are presented as mean ± SEM. *Nonparametric one-way ANOVA-Kruskal-Wallis test. LHP concentration was significantly increased at the end of surgery and started to decrease just after 1 h later reaching the initial level within 48 h. The obtained results indicate limitation of the oxidative stress in the course of uncomplicated healing. The results also suggest that LHP level can be used for monitoring of oxidative stress activity in humans. Figure.
Highlights
Ill patients requiring intensive care are at risk of iatrogenic ocular damage
Intensive Care Unit (ICU) management of critically ill patients often includes the requirement for tracheostomy and feeding access, most often a pecutaneous endoscopic gastrostomy (PEG)
Percutaneous tracheostomy is performed routinely in many medical intensive care unit (ICU) settings, in high risk surgical and trauma patients who often have unstable cervical spine injury and tissue edema, direct visualization of the cervical structures and trachea is imperative during tracheostomy
Summary
Ill patients requiring intensive care are at risk of iatrogenic ocular damage. We designed an experimental situation where external cardiac pressure conditions were controlled and adjusted to physiological extremes to mimic clinically relevant situations, while cardiac performance was assessed using left ventricular pressure–volume relationships (LVPVR) which are relatively preload and afterload independent This prospective, controlled study was undertaken to evaluate the response to therapy aimed at achieving supranormal cardiac and oxygen transport values (cardiac index >4.5 l/min/m2, oxygen delivery >600 l/min/m2, and oxygen consumption >170 l/min/m2) in patients older than 60 or with previous severe cardiorespiratory illnesses, who have undergone elective extensive ablative surgery planned for carcinoma or abdominal aortic aneurism. Whilst some human studies conducted in the critically ill and in high risk surgical patients have suggested that dopexamine may cause an increase in tonometrically measured gastric intra-mucosal pH (pHi) and an improvement in clinical outcome, this has not been confirmed in other randomised trials. In the present study the association of platelet function to inflammatory markers indicating disease severity was investigated
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