Abstract
A gas chromatographic method to monitor halofenate, a hypolipemic agent, provided an accurate means for studying its pharmacokinetics, the correlation of plasma level with pharmacologic effect, and estimation of patient compliance. In double‐blind studies, data on interval sampies showed: (1) plasma half‐life about 2 days; (2) almost complete plasma protein binding of the free acid after oral administration of the ester; (3) very low clearance rate; (4) long duration in over 85% of patients. A once‐a‐day schedule is, therefore, feasible with plasma levels being adequate even if the patient skips a day or more of medication. Cood correlation was demonstrated between total halofenate and triglyceride or urate lowering, but not with cholesterollowering.
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