Abstract
Surface enhanced Raman scattering (SERS) with high detection sensitivity has emerged as a fascinating protocol for monitoring trace amount of drugs in clinical serum sample. Herein, a simple and environmentally friendly photo-induced in-situ reduction strategy was proposed to synthesize RP@Ag composites with both SERS and photocatalytic activities. By carefully adjusting the concentration of the Ag source in the precursor solution, the amount and diameter of the decorated Ag nanoparticles were precisely tuned. The resulting optimal RP@Ag composites exhibited reliable SERS enhancement ability (enhancement factor: 1.76 × 107) and the highest degradation efficiency (degradation ratio: 95.04 %, irradiation time: 120 mins) in recyclable detection of Rhodamine B. After further confirming the reliable accuracy, sensitivity, homogeneity, and durability of the RP@Ag composites, they were used to monitor osimertinib and enabled an extremely low limit of detection as 1.63 × 10−7 mg/mL. In particular, such a recyclable SERS platform achieved perfect recovery rates, the obtained deviations were all within 10 % in the monitoring of clinical samples from patients taking medicine for different durations.
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