Abstract
A method for the determination in vivo of the benzylpenicillin residues in ovine milk at low levels was described. Two groups of Sardinian breed sheep were treated with a dose of penicillin G sodium salt by intramammary infusion and intramuscular administration respectively. The residues were detected by isocratic HPLC method of the extracts obtained from a previous cleanup procedure. Linear calibration plots were obtained over a large concentration range of 1 mg ml −1–10 ng ml −1, with correlation coefficients greater than 0.998. Recoveries between 78.6 and 87.3% were obtained. Limit of detection (LOD) and limit of determination (LOQ) were 2.6 and 8.8 ng ml −1 respectively. This method would be useful for routine monitoring of penicillin G residues in ovine dairy milk.
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