Abstract
This study aims to investigate the impact of selection on scrapie resistance on the genetic variability of Florina sheep breed closed nucleus at the Research Institute of Animal Science, in the region of Central Macedonia, Greece. The complete pedigree dataset of the nucleus flock was used in the study, and the prion protein (PrP) gene polymorphisms were identified for each animal. Three annual selection regimes were simulated, where the selection of the rams and ewes for mating was based on the coancestry value between them and their PrP gene polymorphism. The population structure and pedigree were analyzed to assess the impact of selection on scrapie on the evolution of inbreeding and the effective population size.
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