Monitoring & healing dual channel system designed for continuous glucose monitoring decorated with high-efficient self-healing CuO nanoflakes glucose catalytic electrode

Abstract

Continuous glucose monitoring (CGM) system provides diabetics with an extremely attractive alternative in controlling blood glucose level. Compared with enzymatic and noble meal-based electrode, copper-based electrode presents a better stability and anti-interference property, which is more suitable to be applied in CGM system for long-term working. The investigation of the failure behavior of copper-based electrode is of vital importance for the application in CGM system. In this paper, the damaged mechanism of copper-based electrode was investigated by analyzing the variation of structure and catalytic properties of CuO nanoflakes (NFs) electrode after long-term working. The results indicated that the main reason for the failure of CuO NFs electrode was structure damage. Copper anodization is an effective electrochemical method to construct the nanostructured film in situ and was used to repair the damaged structure. Based on the damaged mechanism of the copper-based catalytic electrode and the dissolution-precipitation mechanism of copper anodization, a monitoring & healing dual channel (M&H) system decorated with highly efficient self-healing CuO NFs electrode was designed for CGM system. The M&H system enable the monitoring and healing process to be achieved by only adjusting the working potential in the same supporting electrolyte (0.1 M NaOH aqueous), which greatly facilitates glucose measurement and has instructive significance for engineering applications in commercial glucose sensors.