Abstract
The efficacy of oral anticoagulant therapy is well established for preventing and treating venous and arterial thromboembolism in a wide variety of clinical settings. In recent years, standardized laboratory monitoring and recognition of the frequency and hazards of overly intense anticoagulation have resulted in major improvements in the safety and efficacy of oral anticoagulant therapy. In this chapter we briefly review issues relating to monitoring chronic anticoagulant therapy and discuss guidelines for achieving and maintaining an optimal level of anticoagulation in clinical settings in which oral anticoagulant therapy is used, such as deep venous thrombosis, pulmonary embolism, atrial fibrillation, prosthetic heart valves, and following myocardial infarction.
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