Abstract
Diffuse correlation spectroscopy (DCS) is an emerging near infrared spectroscopy modality able to measure cerebral blood flow (CBF) non-invasively and continuously in humans. We have reported a limited applicability in adults due to the significant extracerebral tissue thickness and the low signal-to-noise ratio (SNR) of the measurements. Improvements to DCS brain sensitivity and SNR can be achieved by operating DCS at 1064 and using superconducting nanowire single-photon detectors (SNSPDs). Initial human results show a 16-fold improvement in SNR and 20% improvement in depth sensitivity. This allows us to resolve changes in CBF in adult subjects more robustly and accurately than was previously achievable.
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