Abstract
CaMKII (Calcium/calmodulin-dependent protein kinase II) is an important mediator of cellular signaling, calcium homeostasis, heart failure, and lethal cardiac arrhythmias. Recently, CaMKII was reported to reside in mitochondria where it mediates calcium homoeostasis and redox status in the organelle. Current methods of mitochondrial CaMKII detection are limited and rely on imperfect antibody based detection methods that cannot reliably distinguish between isoforms. Here we developed a genetic reporter method using split fluorophores to track mitochondrial CaMKII (mitoCaMKII) accumulation of the δ isoform.
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