Monitoring β-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging: A Proof-of-Concept Study in Individuals With Type 1 Diabetes.

Theodorus J.P Jansen,François Pattou,Amandine Beron,Maarten Brom,Irina Velikyan,Bastiaan E De Galan,Marten A Engelse,Mijke Buitinga,Michiel F Nijhoff,Sebastiaan Van Koeverden,Marinette Van Der Graaf,Marti Boss,Eelco J.P De Koning,Olof Eriksson,Marie-Christine Vantyghem,Martin Gotthardt

doi:10.2337/db22-0884

Monitoring β-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging: A Proof-of-Concept Study in Individuals With Type 1 Diabetes.

Theodorus J.P Jansen, François Pattou + Show 14 more

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https://doi.org/10.2337/db22-0884

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Journal: Diabetes	Publication Date: Apr 17, 2023
Citations: 3	License type: cc-by-nc-sa

Affiliation: Radboud University Nijmegen, Radboud University Nijmegen Medical Centre, Pasteur Institute of Lille, Inserm, University of Lille, Centre Hospitalier Universitaire de Lille, Uppsala University, Maastricht University, Leiden University Medical Center

#Positron Emission Tomography Imaging #Intrahepatic Islet Transplantation + Show 8 more

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Abstract

This clinical study researched the potential of radiolabeled exendin to follow the fate and survival of intrahepatic islet grafts. Is it feasible to quantitatively detect intrahepatic islet transplants with [68Ga]Ga-NODAGA-exendin-4 (68Ga-exendin) positron emission tomography (PET) imaging? Our study findings indicate that the imaging technique 68Ga-exendin PET can be used to monitor viable islet mass after intrahepatic islet transplantation in humans. Alongside functional measures, 68Ga-exendin PET imaging could significantly aid in the evaluation of strategies designed to improve islet engraftment, survival, and function.

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