Abstract
Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes induced by long-term high fat and high fructose diet (HFFD) remain unclear. In this study, RMD, MS, and AK were orally administered to HFFD-fed rats for 10 weeks. The result showed that orally administered MS, AK, and RMD were able to prevent the develop-ment. MS had a more potent effect on lowering blood glucose, fructosamine, and insulin resistance, and increasing hepatic glucose transporters-2, adipocyte glucose transporters-4, and hypoxia-inducible factor 1-α. AK had a greater effect on lowering blood lipid, adipose pad, and adipose inflammatory factors (interlukin-1β, tumor necrosis factor-α, and interlukin-6) levels. Therefore, the prevention of type 2 diabetes and metabolic disorders of RMD could be mainly attributed to the synergistic effect of MS and AK.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.