MON-596 Male Individuals with Autoimmune Thyroid Disease Present Higher Risk for Clustering Other Non-Thyroidal Autoimmune Diseases

Abstract

Background: Autoimmune thyroid disease (ATD) share common pathophysiology pathways with several other autoimmune diseases. It can be a first manifestation of an immunoregulatory diathesis, leading to a cluster of associated autoimmunities. Aim: The present study aimed to evaluate and compare the frequency of Type 1 diabetes (T1DM) and celiac disease (CD) related antibodies among pediatric and adult patients with Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). Methods: A total of 145 individuals, aged 2 to 50 years (114 females; 89 pediatric patients) were included in a cross-sectional descriptive study (74 HT). Determination of antibodies related to T1DM (GADA65 and IA2), CD (tTG-IgA and EMA-IgA) and Anti-Saccharomyces Cerevisiae (ASCA) were performed. Results: Non-thyroidal autoimmune diseases (NTAID) was found in 8.3% of individuals. Males presented a 3.2-time higher risk for a second NTAID (p=0.004) and a 4-time higher risk for a third NTAID (p=0.017). The pediatric group had 53% higher risk for developing a second NTAID (p=0.042). GADA65, IA2 and ASCA-IgG positivity were found in 11%, 2.7% and 14.4% of the individuals, respectively. CD-related antibodies were found in a ratio of 1:48 patients. Conclusion: Individuals with ATD present high rates of T1DM and CD-related antibodies. The male group, regardless of age, has a higher rate of CD-related antibodies and also higher risk for developing two or more NTAIDs. The pediatric population with ATD presents a higher rate of AID clustering than adults. A closer surveillance for associated NTAID throughout follow-up should be performed, mainly in young male group.