MON-257 Cardiovascular and renal risk progression after 15 years of follow up in a Toba aboriginal cohort (preliminary results)

Abstract

Toba aborigines used to share a culture of hunters and gatherers; they got contact with civilization in the late nineteenth century, and, though many of them still live in rural areas, most have moved to suburban areas. During 2003, cardiovascular and renal risk factors (CVRRF) were studied in 385 Toba people living in suburban neighborhoods from Resistencia City (Chaco) one of the poorest regions of Argentina. In 2018, after 15 years, we began to re-study the same population, in order to evaluate mortality and progression of CVRRF. The objective now is to present preliminary results about progression of cardiovascular and renal risk in this suburban Toba cohort 65/340 of the surviving cohort were evaluated again, measuring weight, height, waist circumference (WC), creatinine, fasting glucose, and Proteinuria. CKD and renal risk was defined according to KDIGO Guidelines, GFR by MDRD-4 formula; hypertension as >140 mmHg systolic or ³90mmHg diastolic blood pressure (BP); Diabetes as fasting glucose ³126 mg/dl. Proteinuria as uPr/uCr ratio >150mg/g was considered positive. BMI was classified according to WHO as overweight (³25 and <30) and obesity (³30); Central obesity was defined as WC >102 cm in men and >90 cm in women. The analysis comparing baseline and current data was performed using Cox regression and hazard ratio Results: 65 Toba people, 42 (64.6%) females, mean age 49.3±13.5 years old have been re-evaluated so far. Statistical significance (p<0.05) in increasing quantitative variables were found in relation to: age (15.1±3.4), Systolic and Diastolic BP, WC, Weight, BMI, serum glucose, and MDRD. Negative significative differences were found in serum Creatinine (-0.1±0.009 mg/dl), urine Creatinine, and Protein excretion (-9.5 ± 8.5 mg/dl). Proportion of Toba Aborigines with Central Obesity, obesity, protein excretion taken as qualitative variables (yes/no) increased and are statically significative.(p=0,03). HR for proteinuria 5,20 (1,34-20,47).p=0,001 9 (15%) participants showed DBT now and CKD Renal Risk taken as qualitative variable increased significatively. Our preliminary results in part of the original cohort shows that surviving Toba people have increased weight, systolic and diastolic BP, BMI, and glycemia. Cardiovascular and renal risk increased. The increase in MDRD and reduction of urinary and serum creatinine could be interpreted as consequence of probably hyperfiltration associated to obesity, and the new diagnosed type 2 diabetes patients.