MON-310 POSTERIOR URETHRAL VALVE AT A PAEDIATRIC NEPHROLOGY UNIT IN SOUTH WESTERN NIGERIA

Abstract

Posterior urethral valve (PUV) is the most severe form of obstructive uropathies in the paediatric population occurring exclusively in boys. Management of posterior urethral valves is challenging in many parts of sub-Saharan Africa. To provide data on Posterior urethral valves in sub-Saharan Africa, we reviewed the cases of PUVs seen over a 21 month period. Retrospective study- information was obtained from the paediatric nephrology unit data base of children admitted with a diagnosis of posterior urethral valve between March 2016 and December 2017 Twenty-five cases were seen during the study period. Their ages ranged from 3days to 13 years with the median age been 24 months. The mean age and standard deviation was 42.1 (SD ±57.1). Eight (32%) presented during the first year of life and of this number, one (12.5%) presented in neonatal period. The commonest cause of hospital admission was urosepsis, 37.5% of the urine cultures however yielded no growth, and half of the cases were due to Pseudomonas aeroginosa. 9(32.1%) had surgical intervention (Mohan’s valve ablation or Endoscopic Valve ablation). Thirteen (%) had renal failure Three of the subjects received dialysis and of this number, two had haemodialysis. The in-hospital mortality rate is (12.0%) Posterior urethral valves are not uncommon and remain an important cause of urosepsis and chronic kidney disease in the paediatric population in sub-Saharan Africa. Efforts to further improve outcomes are needed.