Abstract
The endothelial glycocalyx lines the lumen of blood vessels and has protective effects on the microvasculature. Damage to this layer can be detected as an increase of its shed constituents in blood, and an increase in the perfused boundary region (PBR) in sublingual vessels using the novel GlycoCheckTM device. In vitro studies have shown toxic effects of aldosterone and a high-salt environment on the glycocalyx that are attenuated by spironolactone. Spironolactone is known to have antiproteinuric and vasculoprotective effects in kidney transplant recipients (KTR).
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