Abstract
Heparin-free hemodialysis (HD) is a challenging procedure as it increases the risk of clotting in the extracorporeal circuit (ECC) which may lead to significant blood loss causing anemia necessitating blood transfusions, increasing doses of erythropoiesis-stimulating agents (ESAs) and iron supplements, thus adding to the burden of treatment cost. Although intermittent saline flushing (ISF) is a widely adopted method for the prevention of clotting during heparin-free hemodialysis, it is still sensible to find better techniques which can improve patient outcomes.
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