Mometasone furoate 0.1 % ointment and hydrogel: a guide to their use in corticosteroid-responsive dermatoses

Abstract

Mometasone furoate is a potent corticosteroid for dermatological use. Ointment and hydrogel formulations containing 0.1 % (i.e. 1 mg/g) mometasone furoate are effective and well-tolerated options for the topical treatment of corticosteroid-responsive dermatoses. In the treatment of moderate-to severe psoriasis, eczema and atopic dermatitis, the efficacy of mometasone furoate 0.1 % ointment applied once daily was greater than, or similar to, that of several other potent corticosteroids applied twice or three times daily. Mometasone furoate 0.1 % hydrogel, which has been formulated to be more suitable and patient acceptable than lotion formulations, is bioequivalent to mometasone furoate 0.1 % lotion. In the treatment of moderate-to-severe scalp psoriasis, mometasone furoate 0.1 % lotion applied once daily was more effective than other potent corticosteroids applied twice daily. In addition to the advantage of once-daily application, topical mometasone furoate 0.1 % is associated with a low risk of skin atrophy and a very low risk of systemic adverse effects, including the suppression of the hypothalamic-pituitary-adrenal axis.