Abstract
The commercially pure Ti (CP Ti) and equal-channel angular pressing (ECAP) processed Ti can contribute to the downsizing of medical devices with their superior mechanical properties and negligible toxicity. However, the ECAP-processed pure Ti has the risk of bacterial infection. Here, the coarse- and ultrafine-grained Ti substrates were surface-modified with molybdenum disulfide (MoS2) to improve the cell proliferation and growth with antibacterial effect for further dental applications. According to in vitro tests using the pre-osteoblast of MC3T3-E1 cell and a bacterial model of Escherichia coli (E. coli), MoS2 nanoflakes coated and ECAP-processed Ti substrates showed a significant increase in surface energy and singlet oxygen generation resulting in improved cell attachment and antibacterial effect. In addition, we confirmed the stability of the surface modified Ti substrates in a physiological solution and an artificial bone. Taken together, MoS2 modified and ECAP-processed Ti substrates might be successfully harnessed for various dental applications.
Highlights
Technology (POSTECH), Pohang, 37673, Republic of Korea
MoS2 is a prototypical transition metal dichalcogenides (TMDs) material, and it consists of two planes of hexagonally arranged sulfur (S) atoms linked with a hexagonal plane of molybdenum (Mo) atoms
Despite the potential for the cellular and antibacterial behavior of MoS230,35,36 including contact membrane stress, singlet oxygen (O2−) induced reactive oxygen species (ROS) production, the effect of MoS2 nanoflakes coating on the Ti surface for a medical device has not been investigated as far as the authors know
Summary
Technology (POSTECH), Pohang, 37673, Republic of Korea. Myeong Hwan Shin and Seung Mi Baek contributed to this work. Studied and regarded as effective in inhibiting bacterial adhesion. MoS2 is a suitable coating material for mass production process because of its simple coating method with amphiphilic behavior[31] and low cost. Despite the potential for the cellular and antibacterial behavior of MoS230,35,36 including contact membrane stress, singlet oxygen (O2−) induced ROS production, the effect of MoS2 nanoflakes coating on the Ti surface for a medical device has not been investigated as far as the authors know. ECAP-processed pure Ti was reported to enhance the bacterial adhesion[37]. The cellular activities of MoS2 coated pure Ti with the pre-osteoblast cell were carried out in vitro. The ECAP-processed Ti and HF etching were used to investigate the effect of MoS2 coating depending on grain size and etching.
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