Abstract
Development of molecularly imprinted solid-phase extraction (MISPE) sorbents for the removal of drugs from human urine is described. MISPE sorbents are synthesized through free radical polymerization mechanism and non-covalent imprinting approach. After the completion of the polymerization, bulk polymer is ground using an analytical mill and then wet-sieved. Later on, MISPE sorbent has been dry-packed into solid-phase extraction cartridges after the extraction of template drug molecule. Eluates from the cartridges are analyzed using a spectrophotometer or spectrofluorimeter for the determination of target analyte by referring to the calibration curves.
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