Abstract
Molecularly Imprinted Polymers (MIPs) are polymeric networks capable of recognizing determined analytes. Among other methods, non-covalent imprinting has become the most popular synthesis strategy for Molecular Imprinting Technology (MIT). While MIPs are widely used in various scientific fields, one of their most challenging applications lies within pharmaceutical chemistry, namely in therapeutics or various medical therapies. Many studies focus on using hydrogel MIPs in transdermal drug delivery, as the most valuable feature of hydrogels in their application in drug delivery systems that allow controlled diffusion and amplification of the microscopic events. Hydrogels have many advantages over other imprinting materials, such as milder synthesis conditions at lower temperatures or the increase in the availability of biological templates like DNA, protein, and nucleic acid. Moreover, one of the most desirable controlled drug delivery applications is the development of stimuli-responsive hydrogels that can modulate the release in response to changes in pH, temperature, ionic strength, or others. The most important feature of these systems is that they can be designed to operate within a particular human body area due to the possibility of adapting to well-known environmental conditions. Therefore, molecularly imprinted hydrogels play an important role in the development of modern drug delivery systems.
Highlights
Imprinted Polymers (MIPs) are polymeric networks capable of recognizing determined analytes
The mentioned “unusual adsorption properties” have been reported using numerous polymers, which have been subsequently named as molecularly imprinted polymers—Molecularly Imprinted Polymers (MIPs)
The need for creating intelligent materials based on chemical compounds that can mimic the natural receptors inspires the development of imprinting technologies and expand the MIPs synthesis into the synthesis of stimuli-responsive MIPs (SR-MIPs) by stimuliresponsive technology for molecular imprinting
Summary
In comparison other well-known recognition systems, MIPs have received considerable attention. MIPs are used matrices in variousthat fields as purificaMolecularly imprinted polymers arewidely polymeric aresuch moulds for the tion [9], separation [10], and catalysis [11], and degradation processes [12]. They formation of template complementary binding areas. They can be programmed to recognize have become attractive in drug delivery [13], artificial antibodies [14], or biosensing [15]. Whereas MIPs present a wide range of advantages, there is some drawback that should be considered
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