Abstract
Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.
Highlights
The sensing field represents an emerging technology with high capabilities and versatility to detect various analytes in different matrices and detection performance acts a significant function in several basic procedures in many systems [1,2]
Molecularly imprinted polymers (MIPs) can be prepared by different methods
They performed biomarker for diagnosis and prognosis of prostate cancer. They performed with prostate specific with prostate specific antigen solutions in the range of 0.1–50 ng/mL with a low detection limit antigen solutions in the range of 0.1–50 ng/mL with a low detection limit value (91 pg/mL). They evaluated ten clinical samples and presented 98% concurrence between the results found by enzymevalue (91 pg/mL)
Summary
The sensing field represents an emerging technology with high capabilities and versatility to detect various analytes in different matrices and detection performance acts a significant function in several basic procedures in many systems [1,2]. Natural recognition elements have high affinity to their targets but they cannot be used in practical applications because of their poor durability at high pressure, temperature and in organic solvents, and low stability in high and/or low pH buffers. One of the most important modification method, molecular imprinting, has been proposed to defeat most of these drawbacks [3]. This method was first reported by Wulff and Sarhan in the early 1970s [4]. Molecular imprinting method principally bases on the specific molecular recognition to a template molecule [5]. Imprinted polymers (MIPs) can be synthesized by different types and combinations of functional monomers, cross-linkers, initiators and solvents [6,7,8].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
