Abstract
Chemosensing systems were devised for the enantioselective determination ofd- andl-phenylalanine (d- andl-Phe).
Highlights
Until now, high-performance liquid chromatography (HPLC) has widely been used for the separation and quantification of chiral isomers.[3,4,5,6] The use of chiral HPLC columns to separate enantiomers is very common.[7,8] more than one chromatographic system is needed to achieve the desired selectivity if multiple chiral isomers are to be separated.Other than HPLC methods, chemosensing can be an alternative for the selective sensing of enantiomers.[9,10,11] The first chemosensing step involves selective interactions of the analyte with the recognition unit immobilized on a transducer surface
The desired selectivity of molecularly imprinted polymers (MIPs) is obtained by suitable design of their molecular cavities
The results of selectivity studies are summarized in Scheme 2 The experimental setup, based on the Extended-gate field-effect transistors (EG-field-effect transistors (FETs)) design, using an Au-glass slide coated with the phenylalanine-templated MIP film or non-imprinted polymer (NIP) film as the gate, and a Pt plate as the reference electrode (RE)
Summary
High-performance liquid chromatography (HPLC) has widely been used for the separation and quantification of chiral isomers.[3,4,5,6] The use of chiral HPLC columns to separate enantiomers is very common.[7,8] more than one chromatographic system is needed to achieve the desired selectivity if multiple chiral isomers are to be separated.Other than HPLC methods, chemosensing can be an alternative for the selective sensing of enantiomers.[9,10,11] The first chemosensing step involves selective interactions of the analyte with the recognition unit immobilized on a transducer surface. Calibration plots for D-phenylalanine, D-proline, D-alanine, and D-tyrosine at the (D-phenylalanine)-templated MIP film deposited on the Au-glass slide gate (working electrode) of the EG-FET. Calibration plots for L-phenylalanine, D-tyrosine, and D-alanine at the (L-phenylalanine)-templated MIP film deposited on the Au-glass slide gate (working electrode) of the EG-FET.
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