Molecularly imprinted poly[tetra(o-aminophenyl)porphyrin] as a stable and selective coating for the development of voltammetric sensors

Abstract

Molecularly Imprinted poly[tetra(o-aminophenyl)porphyrin] is presented as an electrosynthesized coating for the development of selective microsensors. A carbon fiber microelectrode has been modified with this covering by cyclic voltammetry in the potential range from −0.15 to 1.0 V (scan rate 50 mV s−1) obtaining a microsensor able to recognize the template molecule. To carry out this study dopamine was chosen as model to work with, since this molecule presents electroactivity as it can be oxidized on carbon electrodes. The MIP sensor presented a linear response to the dopamine concentration in the range from 10−6 to 10−4 M with good repeatability (RSD 6.22%). The selectivity shown by the microsensor was found to be excellent as it was able to differentiate between different catecholamines. A method has been developed for the determination of dopamine in brain tissue samples using the MIP microsensor.