Abstract
BackgroundHuman Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs).MethodsTo understand the epidemiology and subtype distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV subtypes.ResultsHAdV was successfully sequenced in 99 (2.4%) of the 4129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%), and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer.ConclusionAll ages suffer adenovirus infections, but young children are at the greatest risk. This study data demonstrates that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.
Highlights
Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups
All ages suffer adenovirus infections, but young children are at the greatest risk
The phylogenetic analysis indicated that 84 patients with HAdV belonged to species B, 7 patients with HAdV belonged to species C, and 8 patients with HAdV belonged to species E (Table 3)
Summary
Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. Limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). Human adenoviruses (HAdV) are non-enveloped doublestranded DNA viruses. 103 genotypes of HAdV have been documented to date They are organized into seven species (A-G) [1, 2]. Among all HAdVs, types 3, 4, 7, 14, 21, and 55 often cause severe infections and have been linked to outbreaks globally [7,8,9,10,11]. HAdVassociated outbreaks are more likely to occur in closed and crowded conditions, such as schools, hospitals, or military recruits [7, 9]
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