Abstract
We introduce a large DNA membrane channel with a ≈ 4 nm diameter pore, which spontaneously inserts into flat lipid bilayer membranes using hydrophobic functionalizations or streptavidin linkages between biotinylated channels and lipids. Using a dye influx assay, we demonstrate formation of membrane pores in giant unilamellar vesicles. The versatility of DNA nanotechnology makes these channels promising molecular devices for synthetic biology and biosensing.
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