Abstract
Objective : To compare treatment in ectopic pregnancy within combination gefitinib, methotrexat and methotrexat only
 Method : Literature Review
 Result : Ectopic pregnancies are serious condition that can be fatal, therefore the prompt therapeutic is essential. There some recent studies explain molecular target therapeutic use combination of gefitinib and methotrexat is more effective inducing placental cell death and can rapidly resolve tubal ectopic pregnancy than methotrexate only. If a large clinical randomized trial confirm these finding, these combination could become a new medical option for ectopic pregnancy
 Conclusion : Combination gefitinib and methotrexate is more effective in ectopic pregnancy than methotrexate only
Highlights
An ectopic pregnancy is a life-threatening condition that occurs when the fertilized ovum implants outside the endometrial cavity
The placenta relies on epidermal growth factor receptor (EGFR) signalling heavily which promotes the cytotrophoblast motility, blocks apoptosis, and protects placental cells when exposed to stressors
Gefitinib is a molecular-targeted drug that selectively blocks EGFR signalling by inhibiting the tyrosine kinase domain of EGFR.[8]
Summary
An ectopic pregnancy is a life-threatening condition that occurs when the fertilized ovum implants outside the endometrial cavity. *Correspondence to: Aditya Prabawa; Department of Obstetrics and Gynecology, Wirasatya Army Hospital Singaraja; adityaprabawa2@gmail.com Alternative treatment has been increasingly applied to treat it since 90’s using methotrexate for small ectopic pregnancy with serum hCG concentration
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