Abstract
In order to establish the molecular targets of 1,4-benzodiazepin-2-ones mediating their influence on the appetite, the ability of 18 representatives of this class of compounds to bind to the central and peripheral benzodiazepine, dopamine (D1, D2), serotonin (5HT1A) and cholecystokinin (CCK2) receptors in the rat brain has been studied. The anorexigenic activity of some compounds is related to their ability to bind to CCK2 receptor, while the orexigenic activity of 7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one (phenazepam) is due to its high affinity to central benzodiazepine receptors.
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