Abstract

Only few antiviral substances have been licensed and/or are widely available for medical use. These include, at present, amantadine and rimantadine for the prophylaxis and early treatment of influenza A virus infections, idoxuridine, trifluridine, vidarabine and acyclovir for the topical treatment of herpetic keratitis, acyclovir for the systemic (intravenous or peroral) treatment of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections, vidarabine for the systemic (intravenous) treatment of herpetic encephalitis (although acyclovir is superior to vidarabine in the treatment of herpetic encephalitis), ribavirin for the topical (aerosol) treatment of respiratory syncytial virus infection in infants, and retrovir (azidothymidine) for the systemic (intravenous or peroral) treatment of AIDS and AIDS-related complex (ARC).1

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