Molecular systems for targeted delivery and controlled release of growth factors for chronic wound treatment

A R Lipunov,M G Gladkova,A V Kibardin,A B Chuhnina,V A Mitish,I M Afanasov,E S Vorobeva

doi:10.25199/2408-9613-2018-5-3-6-15

A R Lipunov, M G Gladkova + Show 5 more

Open Access

https://doi.org/10.25199/2408-9613-2018-5-3-6-15

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Abstract

Growth factors (GFs) are endogenous signaling proteins, that regulate cell migration, proliferation and differentiation in tissue regeneration. GFs’ concentrations in chronic wounds are pathologically reduced. This leads to a disruption of the healing process and makes chronic wounds treatment more complicated. There are drugs currently used in clinical practice, that contain GFs in a free form. However, their efficiency for chronic wounds treatment is limited, as GFs are quickly degraded in a proteolytic environment of chronic wounds. In order to overcome this limitation biocompatible molecular systems for targeted delivery and controlled release are proposed, such as: micro- and nanoparticles, hydrogels, scaffolds. GFs roles in the healing process, chronic wounds pathophysiology and molecular systems for GFs targeted delivery and controlled release are reviewed.

Highlights

Факторы роста (ФР) – это эндогенные сигнальные белки, которые регулируют миграцию, пролиферацию и дифференцировку клеток в процессах репарации тканей
Growth factors (GFs)’ concentrations in chronic wounds are pathologically reduced. This leads to a disruption of the healing process and makes chronic wounds treatment more complicated
There are drugs currently used in clinical practice, that contain GFs in a free form

Summary

Platelets Fibroblasts Macrophages

Выступает в роли хемоаттрактанта для фибробластов, нейтрофилов, моноцитов и гладких мышечных клеток. Активирует высвобождение ФР макрофагами Стимулирует пролиферацию фибробластов и образование внеклеточного матрикса. Acts as chemoattractant for fibroblasts, neutrophils, monocytes, and vascular smooth muscle cells. Activates macrophages-induced growth factor release Stimulates fibroblasts proliferation and ECM formation. Стимулирует ангиогенез Стимулирует пролиферацию и миграцию клеток эндотелия сосудов. Promotes angiogenesis Promotes proliferation and migration of endothelial cells. Стимулирует пролиферацию кератиноцитов, фибробластов и клеток эндотелия сосудов. Promotes proliferation of keratinocytes, fibroblasts, and vascular endothelial cells.

Platelets Fibroblasts Macrophages Keratinocytes

Другие типы Miscellaneous strategies