Abstract
Molecular studies in Treponema pallidum evolution: toward clarity?
Highlights
Syphilis is the best known treponemal infection and the disease has captured the attention of well-known physicians and the imaginations of writers and artists
Two strains (Haiti B and Madras) were isolated from characteristic yaws lesions, yet they have the molecular signatures of the pallidum subspecies
Harper and colleagues [18] have examined a number of chromosomal regions in a total of 23 strains/samples representing the three T. pallidum subspecies and have identified regions of mutation
Summary
Syphilis is the best known treponemal infection and the disease has captured the attention of well-known physicians and the imaginations of writers and artists. Recent molecular studies have identified genetic signatures that can differentiate the existing strains of Treponema pallidum subspecies pallidum (syphilis), subspecies pertenue (yaws), and subspecies endemicum (bejel) [7], yet the molecular bases for the described differences in transmission and clinical course have not been defined. How definitive are these clinical and epidemiological differences? Two strains (Haiti B and Madras) were isolated from characteristic yaws lesions, yet they have the molecular signatures of the pallidum subspecies
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