Molecular Structure, Thermal Reactivity, Spectral Properties and Biological Activities of Hydrazinium Metal(II) and Metal(III) Ethylenediaminetetraacetate Hydrates

Abstract

Hydrazinium metal(II) ethylenediaminetetraacetate dihydrates, [N2H5M(Hedta)](H2O)2 where M = Fe(II), Co(II) or Ni(II) and hydrazinium metal(III) ethylenediaminetetraacetate monohydrates, N2H5[M(edta)(H2O)] where M = Cr(III), Fe(III) or Co(III) have been prepared and characterized by chemical analyses, magnetic moment, electronic and infrared spectra and X-ray powder diffraction studies. The X-ray single crystal structures of Ni(II) and Fe(III) complexes were determined. The nickel complex is octahedral with pentadentate Hedta3− ion and the sixth site is occupied by hydrazinium cation. However, Fe(III) complex is found to be seven coordinated with a hexadentate edta4− anion and a water molecule which occupying the seventh site of the coordination sphere. Both the sets of complexes show enhanced antioxidant activity than their non-hydrazinium counterparts. However, the metal(III) complexes show better antioxidant activity than the corresponding metal(II) complexes. The metal(II) and metal(III) complexes have been also subjected to antiviral screening. These results show that these complexes are active against HSV-1 and HSV-2 viruses. Hydrazinium complexes of metal(II) and metal(III) ethylenediaminetetraacetate hydrates have been synthesized and characterized by analytical, spectral, thermal and X-ray studies. The crystal structures of Ni(II) and Fe(III) complexes have been described. The antioxidant and antiviral studies have also been presented.