Abstract
The inducement of physical, chemical, structural and biological properties to entice of pharmaceutical property was analyzed by Vibrational spectroscopic, biological and theoretical tools. The structural arrangement for describing structure activity was investigated by injecting ligand groups in internal coordinate system by molecular tools (FT adopted IR, Raman, and NMR). Bond length and bond angle strain was pronounced much due to the chemical equivalent forces extension due to the injection of substitutional groups on base compound and thus non-Centro symmetry was processed. The molecular charge depletion profile was thoroughly studied to persuade protonic and electronic delocalization setup for arranging the drug potential. The chemi-equivalent potential exchange was monitored among different parts of the molecule for obtaining drug mechanism. The biological profile was keenly observed to look at the biological ambiance of the present molecule to fabricate advanced drug. The Lipinski five rule parameters; MV = 137.18, LogP = 0.27, HBD = 2, HBA = 2 and TPSA = 46.2 A2 showed the enhancement of additive drug quality. The exchange of oscillating chemical energy in the core and allied carbons of the base skeleton was keenly noted to find the prearranged chemical environment for successful drug mechanism. The non bonded transitions between Lewis acid and base of bonded molecular system were observed to determine the restoring potential to customize drug potential. The drug assistance for enantiomer characteristics of chirality sequence was displayed to expose the toxicity effect of the molecule. The active molecular bondings on different sites of molecule were measured by estimating polarizability and associated biological inhibition was validated.
Highlights
The inducement of physical, chemical, structural and biological properties to entice of pharmaceutical property was analyzed by Vibrational spectroscopic, biological and theoretical tools
2-Amino-1-phenyl-1-propanol is chiral-active amino derivative which belongs to psychoactive drug family and the application of such base compound was to relieve nasal congestion and acted as anorectic agent [1]
This specific chemical compound is fabricated in the base of Phenyl ring in which the hydrocarbon group (CH2CH3) is injected jointly with aliphatic substitution along with amino group
Summary
2-Amino-1-phenyl-1-propanol is chiral-active amino derivative which belongs to psychoactive drug family and the application of such base compound was to relieve nasal congestion and acted as anorectic agent [1]. This specific chemical compound is fabricated in the base of Phenyl ring in which the hydrocarbon group (CH2CH3) is injected jointly with aliphatic substitution along with amino group. Such amino group stressed the joining chain very much and thereby the proportionate chain strain was observed on the alternation of bond parameters. The entire analyses have been made on the model structure as shown in Figure 1 where it was ensured that, the structure was free from trans and cis from
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