Abstract
Stress is the response of the organism to various external and internal events. All response reactions change from metabolic processes to metabolic stresses in minutes or even seconds. The scientists most often discuss oxidative, nitrosative and carbonyl stresses which are characterized by the accumulation of free radicals and other reactive oxygen species, as well as active carbonyl compounds, in the cells and extracellular fluid. These active (signal) molecules are powerful nonspecific modifiers of the structure and function of proteins, lipids, carbohydrates, and they interfere with bioenergetics. Small doses of active signal molecules are necessary for adaptive reactions of the body, they inhibit metabolic disorders, especially protein disorders, but their excessive accumulation causes pathological processes with pronounced modification of proteins and cardiovascular, neurodegenerative, autoimmune, connective tissue diseases and cancer. The authors discuss possible protection and prevention measures of metabolic stress.
Highlights
Stress is the response of the organism to various external and internal events
All response reactions change from metabolic processes to metabolic stresses in minutes or even seconds
The scientists most often discuss oxidative, nitrosative and carbonyl stresses which are characterized by the accumulation of free radicals and other reactive oxygen species, as well as active carbonyl compounds, in the cells and extracellular fluid
Summary
Стрессы возникают в ответ на различные внешние и внутренние воздействия на организм. В секундо-минутный отрезок времени все ответные реакции организма переходят через изменение обменных процессов в развитие метаболических стрессов. The scientists most often discuss oxidative, nitrosative and carbonyl stresses which are characterized by the accumulation of free radicals and other reactive oxygen species, as well as active carbonyl compounds, in the cells and extracellular fluid. Молекулярный стресс и хронические нарушения обмена веществ активные низкомолекулярные соединения, обусловливающие модификацию липидов, углеводов, белков, рецепторов, гормонов, митохондрий, нуклеиновых кислот и даже генома [4,5,6,7]. В дыхательной цепи митохондрий используется 85% кислорода, попадающего в клетку [4, 5], но только 1–2% кислорода восстанавливается в норме с образованием первичного радикала – супероксидного аниона, который быстро преобразуется под действием супероксиддисмутазы в перекись водорода, в отличие от окислительного стресса, при котором избыток свободных радикалов преобразуется в активные формы кислорода [4, 5]. Life threatening diseases with a high degree of positive correlation with oxidative stress [5]
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