Abstract
The first lineage determination is an essential embryonic event in mammalian development that defines the precursors of the embryo proper from the extraembryonic tissue. Cui et al. (this issue) identify one factor that is critical for this lineage‐determination process, which normally results in the segregated expression of the embryonic marker POU5F1 (red) and the extraembryonic marker CDX2 (green) in different cells of the blastocyst. This can be seen here in a Day‐3.5 mouse embryo, counterstained for nuclei (blue). Two cells can be seen beginning the process of hatching from the zona pellucida, which is required for successful implantation.
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