Abstract
Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.
Highlights
Bill Paul’s impact on immunology is broad and enormous
Histamine can be synthesized by bacteria found in contaminated food [18] and in the gut of asthma patients [17, 19], in this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis
We demonstrated that chlorotoxin, which induces mast cell maturation [62], strongly upregulates Hdc gene expression in Bone marrow-derived mast cells (BMMCs) within few hours after the treatment [5]
Summary
Edited by: Joshua Milner, National Institute of Allergy and Infectious Diseases (NIAID), United States. Liam O’Mahony, Swiss Institute of Allergy and Asthma Research (SIAF), Switzerland. Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. We focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis
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