Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin–RNA Complex

Abstract

In the groove: The crystal structure of the bacterial decoding-site RNA in a complex with the antibiotic apramycin reveals how glycoside scaffolds participate in RNA recognition by natural products through the formation of pseudo base pairs and triples. The structure suggests that the inhibitory action of apramycin is based on interaction of the antibiotic with ribosomal protein S12 (see structural model), a control element of ribosome translocation.